BAIT
SPP2
pri2, SPBC17D11.06
DNA primase large subunit Spp2
GO Process (1)
GO Function (0)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
HUS1
SPAC20G4.04c
checkpoint clamp complex protein Hus1
GO Process (2)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Analysis of fission yeast primase defines the checkpoint responses to aberrant S phase initiation.
To investigate the checkpoint response to aberrant initiation, we analyzed the cell cycle checkpoint response induced by mutations of Schizosaccharomyces pombe DNA primase. DNA primase has two subunits, Spp1 and Spp2 (S. pombe primases 1 and 2). Spp1 is the catalytic subunit that synthesizes the RNA primer, which is then extended by DNA polymerase alpha (Polalpha) to synthesize an initiation ... [more]
Mol. Cell. Biol. Nov. 01, 2000; 20(21);7853-66 [Pubmed: 11027257]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID