pri2, SPBC17D11.06
DNA primase large subunit Spp2
GO Process (1)
GO Function (0)
GO Component (5)

Gene Ontology Biological Process

Schizosaccharomyces pombe (972h)


checkpoint clamp complex protein Rad9
GO Process (2)
GO Function (1)
GO Component (4)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Analysis of fission yeast primase defines the checkpoint responses to aberrant S phase initiation.

Tan S, Wang TS

To investigate the checkpoint response to aberrant initiation, we analyzed the cell cycle checkpoint response induced by mutations of Schizosaccharomyces pombe DNA primase. DNA primase has two subunits, Spp1 and Spp2 (S. pombe primases 1 and 2). Spp1 is the catalytic subunit that synthesizes the RNA primer, which is then extended by DNA polymerase alpha (Polalpha) to synthesize an initiation ... [more]

Mol. Cell. Biol. Nov. 01, 2000; 20(21);7853-66 [Pubmed: 11027257]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID