A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Analysis of fission yeast primase defines the checkpoint responses to aberrant S phase initiation.

Tan S, Wang TS

To investigate the checkpoint response to aberrant initiation, we analyzed the cell cycle checkpoint response induced by mutations of Schizosaccharomyces pombe DNA primase. DNA primase has two subunits, Spp1 and Spp2 (S. pombe primases 1 and 2). Spp1 is the catalytic subunit that synthesizes the RNA primer, which is then extended by DNA polymerase alpha (Polalpha) to synthesize an initiation ... [more]

Mol. Cell. Biol. Nov. 01, 2000; 20(21);7853-66 [Pubmed: 11027257]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Curated By

BioGRID

Interaction Summary

SPP2

Gene Ontology Biological Process

Gene Ontology Cellular Component

RAD9