A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway.

Toda T, Niwa H, Nemoto T, Dhut S, Eddison M, Matsusaka T, Yanagida M, Hirata D

Cell morphogenesis is a fundamental phenomenon that involves understanding a number of biological processes including the developmental program, polarity and cell division. Fission yeast sts5 mutant cells are round rather than cylindrical with cortical actin randomly dispersed. Genetic analyses demonstrate that the sts5+ gene is required for maintenance of cell shape during interphase when the cell normally exhibits polarised growth. ... [more]

J. Cell. Sci. Sep. 01, 1996; 109(0);2331-42 [Pubmed: 8886983]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PPB1 STS5	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Yoshida T (1994)	Low	-	BioGRID	246918

Curated By

BioGRID

Interaction Summary

STS5

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [ISM]ribonuclease activity [ISM]

Gene Ontology Cellular Component

PPB1

Gene Ontology Biological Process

Gene Ontology Molecular Function

calcium-dependent protein serine/threonine phosphatase activity [IMP]phosphatase activity [IDA]