POL1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAD51
Gene Ontology Biological Process
- double-strand break repair via homologous recombination [ISS]
- homologous recombination-dependent replication fork processing [IMP]
- mating type switching [IGI]
- meiotic DNA double-strand break formation [TAS]
- meiotic DNA repair synthesis [IMP]
- meiotic gene conversion [IDA]
- mitotic recombination [IGI]
- strand invasion [IDA]
- telomere maintenance [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.
The replication checkpoint kinase Cds1 preserves genome integrity by stabilizing stalled replication forks. Cds1 targets substrates through its FHA domain. The Cds1 FHA domain interacts with Mus81, a subunit of the Mus81-Eme1 structure-specific endonuclease. We report here that Mus81 and Rhp51 are required for generating deletion mutations in fission yeast replication mutants that experience replication stress. A mutation in the ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: mutation frequency (APO:0000198)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAD51 POL1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 3308911 | |
| POL1 RAD51 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 2332735 |
Curated By
- BioGRID