BAIT
LSK1
SPAC2F3.15
P-TEFb-associated cyclin-dependent protein kinase Lsk1
GO Process (3)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
PLO1
SPAC23C11.16
Polo kinase Plo1
GO Process (9)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- mitotic actomyosin contractile ring assembly [IMP]
- mitotic cytokinesis, site selection [IMP]
- positive regulation of barrier septum assembly [IMP]
- positive regulation of protein export from nucleus [IMP]
- positive regulation of septation initiation signaling [IMP]
- regulation of mitotic cytokinesis [IMP]
- regulation of protein localization to mitotic spindle pole body [IMP]
- septation initiation signaling [IMP]
- spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The nuclear kinase Lsk1p positively regulates the septation initiation network and promotes the successful completion of cytokinesis in response to perturbation of the actomyosin ring in Schizosaccharomyces pombe.
Cytokinesis in fission yeast requires the function of an actomyosin-based contractile ring whose constriction is dependent on a signaling module termed the septation initiation network (SIN). In response to minor perturbation of the ring, the duration of SIN signaling is extended concurrently with a delay in nuclear cycle progression. These mechanisms require the conserved phosphatase Clp1p/Flp1p and facilitate the successful ... [more]
Mol. Biol. Cell Jan. 01, 2005; 16(1);358-71 [Pubmed: 15537703]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
- phenotype: heat sensitivity (APO:0000147)
Curated By
- BioGRID