A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast.

Stone M, Hartmann-Petersen R, Seeger M, Bech-Otschir D, Wallace M, Gordon C

Conjugation of proteins to ubiquitin plays a central role for a number of cellular processes including endocytosis, DNA repair and degradation by the 26S proteasome. However, ubiquitination is reversible as a number of deubiquitinating enzymes mediate the disassembly of ubiquitin-protein conjugates. Some deubiquitinating enzymes are associated with the 26S proteasome contributing to and regulating the particle's activity. Here, we characterise ... [more]

J. Mol. Biol. Nov. 26, 2004; 344(3);697-706 [Pubmed: 15533439]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Curated By

BioGRID

Interaction Summary

UBP6

Gene Ontology Biological Process

Gene Ontology Molecular Function

ubiquitin thiolesterase activity [ISM]ubiquitin-specific protease activity [IDA]

Gene Ontology Cellular Component

RPN12