BAIT
RQH1
hus2, rad12, rec9, SPAC2G11.12
RecQ type DNA helicase Rqh1
GO Process (13)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- DNA duplex unwinding [IDA]
- cellular response to DNA damage stimulus [IMP]
- double-strand break repair via homologous recombination [IGI]
- intra-S DNA damage checkpoint [IDA]
- maintenance of rDNA [IMP]
- mitotic DNA replication DNA duplex unwinding [ISO]
- negative regulation of mitotic recombination [IMP]
- postreplication repair [IMP]
- recombinational repair [IGI]
- regulation of mitotic recombination involved in replication fork processing [IMP]
- replication fork processing at rDNA locus [IGI]
- resolution of mitotic recombination intermediates [IMP]
- telomere maintenance [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
RAD54
rhp54, SPAC15A10.03c
DNA-dependent ATPase Rad54/Rhp54
GO Process (5)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombe.
Following replication arrest, multiple cellular responses are triggered to maintain genomic integrity. In fission yeast, the RecQ helicase, Rqh1, plays a critical role in this process. This is demonstrated in Deltarqh1 cells that, following treatment with hydroxyurea (HU), undergo an aberrant mitosis leading to cell death. Previous data suggest that Rqh1 functions with homologous recombination (HR) in recovery from replication ... [more]
Genetics Jun. 01, 2005; 170(2);519-31 [Pubmed: 15802523]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID