BAIT
SKP1
psh1, sph1, SPBC409.05
SCF ubiquitin ligase complex subunit Skp1
GO Process (10)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA, IMP]
- mitotic cytokinetic cell separation [IMP]
- negative regulation of mitotic metaphase/anaphase transition [IMP]
- nuclear envelope organization [IMP]
- protein catabolic process [IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- regulation of mitotic cell cycle [IGI]
- regulation of strand invasion [IDA]
- vacuolar acidification [ISO]
- vacuolar proton-transporting V-type ATPase complex assembly [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability.
The COP9 signalosome (CSN) is known to bind cullin-RING ubiquitin ligases (CRLs) and to promote their activity in vivo. The mechanism of this stimulation has remained enigmatic because CSN's intrinsic and associated enzymatic activities paradoxically inhibit CRL activity in vitro. Reconciling this paradox, we show here that Csn5-catalysed cullin (Cul) deneddylation and Ubp12-mediated deubiquitination cooperate in maintaining the stability of ... [more]
Nat. Cell Biol. Apr. 01, 2005; 7(4);387-91 [Pubmed: 15793566]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID