A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.

Publication

An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Yuasa T, Hayashi T, Ikai N, Katayama T, Aoki K, Obara T, Toyoda Y, Maruyama T, Kitagawa D, Takahashi K, Nagao K, Nakaseko Y, Yanagida M

The small genome of fission yeast Schizosaccharomyces pombe contains 4824 predicted genes and gene disruption suggests that approximately 850 are essential for viability. To obtain information on interactions among genes required for chromosome segregation, an approach called Strategy B was taken using mass transformation of the 1015 temperature-sensitive (ts) mutants that were made by random mutagenesis and transformed by plasmids ... [more]

Genes Cells Nov. 01, 2004; 9(11);1069-82 [Pubmed: 15507118]

Throughput

Low Throughput

Ontology Terms

phenotype: heat sensitivity (APO:0000147)
phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CDC48 CUT2	Dosage Lethality Dosage Lethality A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.	Ikai N (2006)	Low	-	BioGRID	436285
CDC48 CUT2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Ikai N (2006)	Low	-	BioGRID	248198

Curated By

BioGRID

Interaction Summary

CDC48

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATPase activity [NAS]protein binding [IPI]

Gene Ontology Cellular Component

CUT2