BAIT

NSE4

rad62, SPBC20F10.04c
Smc5-6 complex non-SMC subunit Nse4
GO Process (3)
GO Function (1)
GO Component (3)
Schizosaccharomyces pombe (972h)
PREY

RAD60

SPBC1921.02
DNA repair protein Rad60
GO Process (4)
GO Function (1)
GO Component (1)
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.

Morikawa H, Morishita T, Kawane S, Iwasaki H, Carr AM, Shinagawa H

Smc5 and Smc6 proteins form a heterodimeric SMC (structural maintenance of chromosome) protein complex like SMC1-SMC3 cohesin and SMC2-SMC4 condensin, and they associate with non-SMC proteins Nse1 and Nse2 stably and Rad60 transiently. This multiprotein complex plays an essential role in maintaining chromosome integrity and repairing DNA double strand breaks (DSBs). This study characterizes a Schizosaccharomyces pombe mutant rad62-1, which ... [more]

Mol. Cell. Biol. Nov. 01, 2004; 24(21);9401-13 [Pubmed: 15485909]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
NSE4 RAD60
Dosage Rescue
Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Low-BioGRID
426399
RAD60 NSE4
Dosage Rescue
Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Low-BioGRID
426403

Curated By

  • BioGRID