rad62, SPBC20F10.04c
Smc5-6 complex non-SMC subunit Nse4
GO Process (3)
GO Function (1)
GO Component (3)
Schizosaccharomyces pombe (972h)


Rad18 homolog ubiquitin protein ligase E3, Rhp18
GO Process (4)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.

Morikawa H, Morishita T, Kawane S, Iwasaki H, Carr AM, Shinagawa H

Smc5 and Smc6 proteins form a heterodimeric SMC (structural maintenance of chromosome) protein complex like SMC1-SMC3 cohesin and SMC2-SMC4 condensin, and they associate with non-SMC proteins Nse1 and Nse2 stably and Rad60 transiently. This multiprotein complex plays an essential role in maintaining chromosome integrity and repairing DNA double strand breaks (DSBs). This study characterizes a Schizosaccharomyces pombe mutant rad62-1, which ... [more]

Mol. Cell. Biol. Nov. 01, 2004; 24(21);9401-13 [Pubmed: 15485909]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID