BAIT

DPB4

SPBC3D6.09
DNA polymerase epsilon subunit Dpb4
GO Process (1)
GO Function (0)
GO Component (4)

Gene Ontology Biological Process

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Identification and cloning of two putative subunits of DNA polymerase epsilon in fission yeast.

Spiga MG, D'Urso G

DNA polymerase epsilon (Pol epsilon) is a multi-subunit enzyme required for the initiation of chromosomal DNA replication. Here, we report the cloning of two fission yeast genes, called dpb3+ and dpb4+ that encode proteins homologous to the two smallest subunits of Pol epsilon. Although Dpb4 is not required for cell viability, Deltadpb4 mutants are synthetically lethal with mutations in four ... [more]

Nucleic Acids Res. Sep. 25, 2004; 32(16);4945-53 [Pubmed: 15388803]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID