A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.

Noguchi E, Noguchi C, McDonald WH, Yates JR, Russell P

Swi1 is required for programmed pausing of replication forks near the mat1 locus in the fission yeast Schizosaccharomyces pombe. This fork pausing is required to initiate a recombination event that switches mating type. Swi1 is also needed for the replication checkpoint that arrests division in response to fork arrest. How Swi1 accomplishes these tasks is unknown. Here we report that ... [more]

Mol. Cell. Biol. Oct. 01, 2004; 24(19);8342-55 [Pubmed: 15367656]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
MUS81 SWI1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Vejrup-Hansen R (2010)	Low	-	BioGRID	482626
MUS81 SWI1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Willis N (2009)	Low	-	PomBase	-

Curated By

BioGRID

Interaction Summary

SWI1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [IDA]chromatin binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

MUS81

Gene Ontology Biological Process

Gene Ontology Molecular Function

crossover junction endodeoxyribonuclease activity [IDA]protein binding [IPI]