DNA topoisomerase III
Schizosaccharomyces pombe (972h)


ATRIP, ATR checkpoint kinase regulatory subunit Rad26
GO Process (1)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity.

Win TZ, Goodwin A, Hickson ID, Norbury CJ, Wang SW

In Schizosaccharomyces pombe, topoisomerase III is encoded by a single gene, top3(+), which is essential for cell viability and proper chromosome segregation. Deletion of rqh1(+), which encodes the sole RecQ family helicase in S. pombe, suppresses the lethality caused by loss of top3. Here, we provide evidence suggesting that the lethality in top3 mutants is due to accumulation of aberrant ... [more]

J. Cell. Sci. Sep. 15, 2004; 117(0);4769-78 [Pubmed: 15340008]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID