BAIT
BTN1
SPAC607.09c
battenin CLN3 family protein
GO Process (8)
GO Function (0)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
VMA1
SPAC343.05
V-type ATPase V1 domain, subunit A
GO Process (5)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.
We have cloned the Schizosaccharomyces pombe homologue of the human Batten disease gene, CLN3. This gene, btn1, encodes a predicted transmembrane protein that is 30% identical and 48% similar to its human counterpart. Cells deleted for btn1 were viable but had enlarged and more alkaline vacuoles. Conversely overexpression of Btn1p reduced both vacuole diameter and pH. Thus Btn1p regulates vacuole ... [more]
J. Cell. Sci. Dec. 01, 2005; 118(0);5525-36 [Pubmed: 16291725]
Throughput
- Low Throughput
Ontology Terms
- cytokinesis (APO:0000071)
- heat sensitivity (APO:0000147)
- inviable (APO:0000112)
Curated By
- BioGRID