PREY

VMA1

SPAC343.05
V-type ATPase V1 domain, subunit A
GO Process (5)
GO Function (0)
GO Component (3)
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.

Gachet Y, Codlin S, Hyams JS, Mole SE

We have cloned the Schizosaccharomyces pombe homologue of the human Batten disease gene, CLN3. This gene, btn1, encodes a predicted transmembrane protein that is 30% identical and 48% similar to its human counterpart. Cells deleted for btn1 were viable but had enlarged and more alkaline vacuoles. Conversely overexpression of Btn1p reduced both vacuole diameter and pH. Thus Btn1p regulates vacuole ... [more]

J. Cell. Sci. Dec. 01, 2005; 118(0);5525-36 [Pubmed: 16291725]

Throughput

  • Low Throughput

Ontology Terms

  • cytokinesis (APO:0000071)
  • heat sensitivity (APO:0000147)
  • inviable (APO:0000112)

Curated By

  • BioGRID