MST2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TAZ1
Gene Ontology Biological Process
- attachment of telomeric heterochromatin to spindle pole body [IMP]
- cellular protein localization [IGI, IMP]
- chromatin silencing at silent mating-type cassette [TAS]
- chromatin silencing at telomere [IMP]
- double-strand break repair [IMP]
- mitotic telomere maintenance via semi-conservative replication [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- protection from non-homologous end joining at telomere [IGI, IMP]
- telomere maintenance [IGI]
- telomeric 3' overhang formation [IGI]
- telomeric loop formation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing.
Histone acetylation and deacetylation are associated with transcriptional activity and the formation of constitutively silent heterochromatin. Increasingly, histone acetylation is also implicated in other chromosome transactions, including replication and segregation. We have cloned the only Schizosaccharomyces pombe MYST family histone acetyltransferase genes, mst1(+) and mst2(+). Mst1p, but not Mst2p, is essential for viability. Both proteins are localized to the nucleus ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TAZ1 MST2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.6312 | BioGRID | 764627 |
Curated By
- BioGRID