SRS2
Gene Ontology Biological Process
Gene Ontology Cellular Component
FBH1
Gene Ontology Biological Process
- DNA duplex unwinding [IDA]
- DNA recombination [IGI]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]
- double-strand break repair via homologous recombination [IGI]
- protein ubiquitination [IDA]
- regulation of DNA recombination [IGI]
- regulation of strand invasion [IDA]
- replication fork processing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
The F-Box DNA helicase Fbh1 prevents Rhp51-dependent recombination without mediator proteins.
A key step in homologous recombination is the loading of Rad51 onto single-stranded DNA to form a nucleoprotein filament that promotes homologous DNA pairing and strand exchange. Mediator proteins, such as Rad52 and Rad55-Rad57, are thought to aid filament assembly by overcoming an inhibitory effect of the single-stranded-DNA-binding protein replication protein A. Here we show that mediator proteins are also ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SRS2 FBH1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.777 | BioGRID | 524993 | |
| FBH1 SRS2 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | -146 | BioGRID | 299821 | |
| FBH1 SRS2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 248122 |
Curated By
- BioGRID