KLP6
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IDA]
- meiotic nuclear division [IMP]
- microtubule cytoskeleton organization involved in mitosis [IMP]
- mitotic actomyosin contractile ring assembly [IMP]
- mitotic sister chromatid segregation [IMP]
- regulation of microtubule depolymerization [IMP]
- regulation of microtubule polymerization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DAD1
Gene Ontology Biological Process
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast.
We identified a truncated allele of dam1 as a multicopy suppressor of the sensitivity of cdc13-117 (cyclin B) and mal3-1 (EB-1) cells to thiabendazole, a microtubule poison. We find that Dam1 binds to the plus end of spindle microtubules and kinetochores as cells enter mitosis and this is dependent on other components of the fission yeast DASH complex, including Ask1, ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DAD1 KLP6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -15.8729 | BioGRID | 523812 | |
| DAD1 KLP6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -9.3225 | BioGRID | 783162 | |
| KLP6 DAD1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -9.3225 | BioGRID | 786060 | |
| KLP6 DAD1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | -184 | BioGRID | 299603 |
Curated By
- BioGRID