A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Protein O-mannosylation is crucial for cell wall integrity, septation and viability in fission yeast.

Willer T, Brandl M, Sipiczki M, Strahl S

Protein O-mannosyltransferases (PMTs) initiate the assembly of O-mannosyl glycans, which are of fundamental importance in eukaryotes. The PMT family, which is classified into PMT1, PMT2 and PMT4 subfamilies, is evolutionarily conserved. Despite the fact that PMTs are crucial for viability of baker's yeast as well as of mouse, recent studies suggested that there are significant differences in the organization and ... [more]

Mol. Microbiol. Jul. 01, 2005; 57(1);156-70 [Pubmed: 15948957]

Throughput

Low Throughput

Ontology Terms

inviable (APO:0000112)

Curated By

BioGRID

Interaction Summary

OGM1

Gene Ontology Biological Process

Gene Ontology Molecular Function

dolichyl-phosphate-mannose-protein mannosyltransferase activity [IDA]

Gene Ontology Cellular Component

OGM4