A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Homolog of BRCA2-interacting Dss1p and Uap56p link Mlo3p and Rae1p for mRNA export in fission yeast.

Thakurta AG, Gopal G, Yoon JH, Kozak L, Dhar R

The breast cancer tumor suppressor BRCA2-interacting protein, DSS1, and its homologs are critical for DNA recombination in eukaryotic cells. We found that Dss1p, along with Mlo3p and Uap56p, Schizosaccharomyces pombe homologs of two messenger RNA (mRNA) export factors of the NXF-NXT pathway, is required for mRNA export in S. pombe. Previously, we showed that the nuclear pore-associated Rae1p is an ... [more]

EMBO J. Jul. 20, 2005; 24(14);2512-23 [Pubmed: 15990877]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
MEX67 MLO3	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Thakurta AG (2005)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

MLO3

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [ISO]protein binding [IPI]

Gene Ontology Cellular Component

MEX67