BAIT

SMC6

rad18, SPCC5E4.06
Smc5-6 complex SMC subunit Smc6
GO Process (3)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

SLX1

SPAP27G11.15
structure-specific endonuclease catalytic subunit
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Brc1-mediated DNA repair and damage tolerance.

Sheedy DM, Dimitrova D, Rankin JK, Bass KL, Lee KM, Tapia-Alveal C, Harvey SH, Murray JM, O'Connell MJ

The structural maintenance of chromosome (SMC) proteins are key elements in controlling chromosome dynamics. In eukaryotic cells, three essential SMC complexes have been defined: cohesin, condensin, and the Smc5/6 complex. The latter is essential for DNA damage responses; in its absence both repair and checkpoint responses fail. In fission yeast, the UV-C and ionizing radiation (IR) sensitivity of a specific ... [more]

Genetics Oct. 01, 2005; 171(2);457-68 [Pubmed: 15972456]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: resistance to chemicals (APO:0000087)
  • phenotype: inviable (APO:0000112)

Additional Notes

  • the smc6-74/slx1 double mutant shows severe sensitivity to MMS (CID 4156 CHEBI 25255)

Curated By

  • BioGRID