BAIT
DNA2
SPBC16D10.04c
DNA replication endonuclease-helicase Dna2
GO Process (10)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [ISO]
- DNA catabolic process, exonucleolytic [IDA]
- DNA duplex unwinding [ISO]
- DNA repair [ISS]
- removal of RNA primer involved in mitotic DNA replication [IMP]
- replication fork processing [IMP]
- replication fork reversal [IMP]
- response to intra-S DNA damage checkpoint signaling [IMP]
- telomere maintenance [IGI]
- telomeric 3' overhang formation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
RAD51
rhp51, SPAC644.14c
RecA family recombinase Rad51/Rhp51
GO Process (9)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- double-strand break repair via homologous recombination [ISS]
- homologous recombination-dependent replication fork processing [IMP]
- mating type switching [IGI]
- meiotic DNA double-strand break formation [TAS]
- meiotic DNA repair synthesis [IMP]
- meiotic gene conversion [IDA]
- mitotic recombination [IGI]
- strand invasion [IDA]
- telomere maintenance [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Genetic and physical interactions between Schizosaccharomyces pombe Mcl1 and Rad2, Dna2 and DNA polymerase alpha: evidence for a multifunctional role of Mcl1 in DNA replication and repair.
Schizosaccharomyces pombe rad2 is involved in Okazaki fragments processing during lagging-strand DNA replication. Previous studies identified several slr mutants that are co-lethal with rad2Delta and sensitive to methyl methanesulfonate as single mutants. One of these mutants, slr3-1, is characterized here. Complementation and sequence analyses show that slr3-1 (mcl1-101) is allelic to mcl1(+), which is required for chromosome replication, cohesion and ... [more]
Curr. Genet. Jul. 01, 2005; 48(1);34-43 [Pubmed: 15915339]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID