CDC48
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [ISO]
- establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site [IMP]
- protein processing [IMP]
- regulation of mitotic sister chromatid segregation [IGI]
- ribosome-associated ubiquitin-dependent protein catabolic process [ISO]
- ubiquitin-dependent protein catabolic process [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CUT1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Cdc48 is required for the stability of Cut1/separase in mitotic anaphase.
Separase, a large protease essential for sister chromatid separation, cleaves the cohesin subunit Scc1/Rad21 during anaphase and leads to dissociation of the link between sister chromatids. Securin, a chaperone and inhibitor of separase, is ubiquitinated by APC/cyclosome, and degraded by 26S proteasome in anaphase. Cdc48/VCP/p97, an AAA ATPase, is involved in a variety of cellular activities, many of which are ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC48 CUT1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 247874 |
Curated By
- BioGRID