Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

N-Acetyl-D-Glucosamine Kinase Interacts with Dynein-Lis1-NudE1 Complex and Regulates Cell Division.

Sharif SR, Islam A, Moon IS

N-acetyl-D-glucosamine kinase (GlcNAc kinase or NAGK) primarily catalyzes phosphoryl transfer to GlcNAc during amino sugar metabolism. Recently, it was shown NAGK interacts with dynein light chain roadblock type 1 (DYNLRB1) and upregulates axo-dendritic growth, which is an enzyme activity-independent, non-canonical structural role. The authors examined the distributions of NAGK and NAGK-dynein complexes during the cell cycle in HEK293T cells. NAGK ... [more]

Mol. Cells Sep. 01, 2016; 39(9);669-79 [Pubmed: 27646688]

Throughput

Low Throughput

Additional Notes

Curated By

BioGRID

Interaction Summary

NAGK

Gene Ontology Biological Process

Gene Ontology Molecular Function

N-acetylglucosamine kinase activity [IDA]protein binding [IPI]

Gene Ontology Cellular Component

DYNLRB1