BAIT
ITCH
6720481N21Rik, 8030492O04Rik, A130065M08, AIP4, C230047C07Rik, RP23-87L24.1
itchy, E3 ubiquitin protein ligase
GO Process (15)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- negative regulation of JNK cascade [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of alpha-beta T cell proliferation [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of defense response to virus [IMP, ISO]
- positive regulation of T cell anergy [IMP]
- positive regulation of protein catabolic process [IDA, IMP]
- protein K29-linked ubiquitination [ISO]
- protein K48-linked ubiquitination [IMP, ISO]
- protein K63-linked ubiquitination [ISO]
- protein polyubiquitination [IDA]
- protein ubiquitination [IBA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of protein deubiquitination [IMP]
- ubiquitin-dependent protein catabolic process [IDA, ISA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MCPT9
MMCP-1, MMCP-9, MMCP9
mast cell protease 9
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5.
Intestinal fibrosis is a major complication in inflammatory bowel diseases, but the regulatory mechanism that inhibits fibrosis remains unclear. Here we demonstrate that Itch-/-myofibroblasts express increased amounts of profibrotic collagen type I and α-SMA in response to IL-17. Mechanistically, we demonstrate that Itch directly binds to HIC-5 and targets it for K63-linked ubiquitination to inhibit IL-17-driven intestinal fibrosis. Reconstitution of ... [more]
Mucosal Immunol Dec. 01, 2017; 11(2);427-436 [Pubmed: 28612841]
Throughput
- High Throughput
Curated By
- BioGRID