BAIT
PYHIN1
IFIX, RP11-520H16.1
pyrin and HIN domain family, member 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ANKRD17
GTAR, NY-BR-16
ankyrin repeat domain 17
GO Process (8)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- defense response to bacterium [IDA]
- innate immune response [IDA]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of MDA-5 signaling pathway [IDA]
- positive regulation of RIG-I signaling pathway [IDA]
- positive regulation of cell cycle [IMP]
- regulation of DNA replication [IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Human antiviral protein IFIX suppresses viral gene expression during HSV-1 infection and is counteracted by virus-induced proteasomal degradation.
The interferon inducible protein X (IFIX), a member of the PYHIN family, was recently recognized as an antiviral factor against infection with herpes simplex virus 1 (HSV-1). IFIX binds viral DNA upon infection and promotes antiviral cytokines expression. How IFIX exerts its host defense functions and whether it is inhibited by the virus remains unknown. Here, we integrated live cell ... [more]
Mol. Cell Proteomics Jan. 11, 2017; 0(); [Pubmed: 28077445]
Throughput
- High Throughput
Curated By
- BioGRID