BAIT

SPG1

sid3, SPAC1565.06c
GTPase Spg1
GO Process (3)
GO Function (2)
GO Component (1)
Schizosaccharomyces pombe (972h)
PREY

SID4

SPBC244.01c
SIN component scaffold protein Sid4
Schizosaccharomyces pombe (972h)

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Sid4p is required to localize components of the septation initiation pathway to the spindle pole body in fission yeast.

Chang L, Gould KL

A mutation in the Schizosaccharomyces pombe sid4(+) (septation initiation defective) gene was isolated in a screen for mutants defective in cytokinesis. We have cloned sid4(+) and have found that sid4(+) encodes a previously unknown 76.4-kDa protein that localizes to the spindle pole body (SPB) throughout the cell cycle. Sid4p is required for SPB localization of key regulators of septation initiation, ... [more]

Proc. Natl. Acad. Sci. U.S.A. May. 09, 2000; 97(10);5249-54 [Pubmed: 10805785]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SPG1 SID4
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-PomBase
-
SID4 SPG1
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
246402

Curated By

  • BioGRID