SLC25A46
MUL1
Gene Ontology Biological Process
- activation of JUN kinase activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- cellular response to exogenous dsRNA [IDA]
- mitochondrial fission [IMP]
- mitochondrion localization [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of chemokine (C-C motif) ligand 5 production [IMP]
- negative regulation of defense response to virus by host [IMP]
- negative regulation of innate immune response [IMP]
- negative regulation of mitochondrial fusion [IDA]
- negative regulation of protein kinase B signaling [IDA]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of protein sumoylation [IDA]
- protein stabilization [IMP]
- protein ubiquitination [IDA]
- regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.
SCL25A46 is a mitochondrial carrier protein that surprisingly localizes to the outer membrane and is distantly related to Ugo1. Here we show that a subset of SLC25A46 interacts with mitochondrial dynamics components and the MICOS complex. Decreased expression of SLC25A46 results in increased stability and oligomerization of MFN1 and MFN2 on mitochondria, promoting mitochondrial hyperfusion. A mutation at L341P causes ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SLC25A46 MUL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | High | - | BioGRID | - |
Curated By
- BioGRID