SLC25A46
MFF
Gene Ontology Biological Process
- mitochondrial fission [ISS]
- mitochondrial fragmentation involved in apoptotic process [IMP]
- mitochondrial fusion [IMP]
- mitochondrion morphogenesis [IMP]
- peroxisome fission [IMP]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of protein targeting to membrane [IDA]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- protein homooligomerization [IDA]
- protein targeting to mitochondrion [IMP]
- regulation of mitochondrion organization [IMP]
- regulation of peroxisome organization [IMP]
- release of cytochrome c from mitochondria [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.
SCL25A46 is a mitochondrial carrier protein that surprisingly localizes to the outer membrane and is distantly related to Ugo1. Here we show that a subset of SLC25A46 interacts with mitochondrial dynamics components and the MICOS complex. Decreased expression of SLC25A46 results in increased stability and oligomerization of MFN1 and MFN2 on mitochondria, promoting mitochondrial hyperfusion. A mutation at L341P causes ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC25A46 MFF | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 1 | BioGRID | 2858971 |
Curated By
- BioGRID