BAIT
SLC25A46
solute carrier family 25, member 46
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
PLD6
ZUC
phospholipase D family, member 6
GO Process (10)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- DNA methylation involved in gamete generation [ISS]
- P granule organization [ISS]
- glycerophospholipid biosynthetic process [TAS]
- meiotic nuclear division [ISS]
- mitochondrial fusion [IMP]
- phosphatidylglycerol biosynthetic process [TAS]
- phospholipid metabolic process [TAS]
- piRNA metabolic process [ISS]
- small molecule metabolic process [TAS]
- spermatid development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.
SCL25A46 is a mitochondrial carrier protein that surprisingly localizes to the outer membrane and is distantly related to Ugo1. Here we show that a subset of SLC25A46 interacts with mitochondrial dynamics components and the MICOS complex. Decreased expression of SLC25A46 results in increased stability and oligomerization of MFN1 and MFN2 on mitochondria, promoting mitochondrial hyperfusion. A mutation at L341P causes ... [more]
Mol. Biol. Cell Mar. 01, 2017; 28(5);600-612 [Pubmed: 28057766]
Throughput
- High Throughput
Curated By
- BioGRID