TXNRD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
THRA
Gene Ontology Biological Process
- gene expression [TAS]
- hormone-mediated signaling pathway [IDA]
- negative regulation of DNA-templated transcription, initiation [IDA]
- negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- TBP-class protein binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- thyroid hormone binding [IDA, IPI]
- thyroid hormone receptor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- TBP-class protein binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- thyroid hormone binding [IDA, IPI]
- thyroid hormone receptor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling.
The selenoprotein thioredoxin reductase (TrxR1) is an integral part of the thioredoxin system. It serves to transfer electrons from NADPH to thioredoxin leading to its reduction. Interestingly, recent work has indicated that thioredoxin reductase can regulate the activity of transcription factors such as p53, hypoxia-inducible factor, and AP-1. Here, we describe that an alternative splicing variant of thioredoxin reductase (TrxR1b) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID