BAIT
AAR2
C20orf4, CGI-23
AAR2 splicing factor homolog (S. cerevisiae)
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
DSP
DCWHKTA, DP, DPI, DPII
desmoplakin
GO Process (12)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- apoptotic process [TAS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- desmosome organization [ISS]
- epidermis development [TAS]
- intermediate filament organization [ISS]
- keratinocyte differentiation [IDA]
- peptide cross-linking [IDA]
- protein localization to adherens junction [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- ventricular cardiac muscle cell action potential [IMP]
- ventricular compact myocardium morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.
Splicing is catalyzed by the spliceosome, a complex of five major small nuclear ribonucleoprotein particles (snRNPs). The pre-mRNA splicing factor PRPF8 is a crucial component of the U5 snRNP, and together with EFTUD2 and SNRNP200, it forms a central module of the spliceosome. Using quantitative proteomics, we identified assembly intermediates containing PRPF8, EFTUD2, and SNRNP200 in association with the HSP90/R2TP ... [more]
J. Cell Biol. Dec. 05, 2016; 216(6);1579-1596 [Pubmed: 28515276]
Throughput
- High Throughput
Curated By
- BioGRID