BAIT
EGLN1
AI503754, C1orf12, HIF-PH2, HPH-2, Hif-p4h-2, ORF13, Phd2, SM-20
egl-9 family hypoxia-inducible factor 1
GO Process (13)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- cardiac muscle tissue morphogenesis [IMP]
- heart trabecula formation [IMP]
- labyrinthine layer development [IMP]
- negative regulation of cAMP catabolic process [ISO]
- negative regulation of cyclic-nucleotide phosphodiesterase activity [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- oxidation-reduction process [ISO]
- oxygen homeostasis [ISO]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [ISO]
- regulation of angiogenesis [IMP]
- response to hypoxia [ISO]
- response to nitric oxide [ISO]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- enzyme binding [ISO]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [ISO]
- peptidyl-proline 4-dioxygenase activity [ISO]
- peptidyl-proline dioxygenase activity [ISO]
- enzyme binding [ISO]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [ISO]
- peptidyl-proline 4-dioxygenase activity [ISO]
- peptidyl-proline dioxygenase activity [ISO]
Mus musculus
PREY
FKBP8
FKBP38, FKBPr38
FK506 binding protein 8, 38kDa
GO Process (3)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of Small-Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor.
The prolyl hydroxylase domain (PHD) protein:hypoxia inducible factor (HIF) pathway is the main pathway by which changes in oxygen concentration are transduced to changes in gene expression. In mammals, there are three PHD paralogues, and PHD2 has emerged as a particularly critical one for regulating HIF target genes such as erythropoietin (EPO), which controls red cell mass and hematocrit. PHD2 ... [more]
Chembiochem Dec. 14, 2016; 17(24);2316-2323 [Pubmed: 27770548]
Throughput
- Low Throughput
Curated By
- BioGRID