BAIT
NKX2-1
BCH, BHC, NK-2, NKX2.1, NKX2A, T/EBP, TEBP, TITF1, TTF-1, TTF1
NK2 homeobox 1
GO Process (15)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- brain development [IMP]
- epithelial tube branching involved in lung morphogenesis [IEP]
- forebrain development [IEP]
- globus pallidus development [IMP]
- lung development [IEP]
- negative regulation of cell migration [IDA]
- negative regulation of epithelial to mesenchymal transition [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- positive regulation of circadian rhythm [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- response to hormone [IEP]
- thyroid gland development [IEP, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [ISS]
- nucleus [IDA]
Homo sapiens
PREY
LMNA
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, RP11-54H19.1
lamin A/C
GO Process (14)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular protein metabolic process [TAS]
- cellular response to hypoxia [IEP]
- endoplasmic reticulum unfolded protein response [TAS]
- establishment or maintenance of microtubule cytoskeleton polarity [ISS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- mitotic nuclear envelope reassembly [TAS]
- muscle organ development [IMP]
- positive regulation of cell aging [IDA]
- protein localization to nucleus [ISS]
- regulation of cell migration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.
TTF-1, also known as NKX2-1, is a transcription factor that has indispensable roles in both lung development and physiology. We and others have reported that TTF-1 frequently exhibits high expression with increased copy number in lung adenocarcinomas, and also has a role as a lineage-survival oncogene through transcriptional activation of crucial target genes including ROR1 and LMO3. In the present ... [more]
Oncogene Feb. 13, 2017; 0(); [Pubmed: 28192407]
Throughput
- High Throughput
Curated By
- BioGRID