BAIT
NKX2-1
BCH, BHC, NK-2, NKX2.1, NKX2A, T/EBP, TEBP, TITF1, TTF-1, TTF1
NK2 homeobox 1
GO Process (15)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- brain development [IMP]
- epithelial tube branching involved in lung morphogenesis [IEP]
- forebrain development [IEP]
- globus pallidus development [IMP]
- lung development [IEP]
- negative regulation of cell migration [IDA]
- negative regulation of epithelial to mesenchymal transition [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- positive regulation of circadian rhythm [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- response to hormone [IEP]
- thyroid gland development [IEP, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [ISS]
- nucleus [IDA]
Homo sapiens
PREY
LMNB1
ADLD, LMN, LMN2, LMNB
lamin B1
GO Process (2)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.
TTF-1, also known as NKX2-1, is a transcription factor that has indispensable roles in both lung development and physiology. We and others have reported that TTF-1 frequently exhibits high expression with increased copy number in lung adenocarcinomas, and also has a role as a lineage-survival oncogene through transcriptional activation of crucial target genes including ROR1 and LMO3. In the present ... [more]
Oncogene Feb. 13, 2017; 0(); [Pubmed: 28192407]
Throughput
- High Throughput
Curated By
- BioGRID