BAIT
SIAH2
hSiah2
siah E3 ubiquitin protein ligase 2
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- axon guidance [TAS]
- cellular protein catabolic process [IGI]
- negative regulation of apoptotic process [IMP]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of nucleic acid-templated transcription [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UBE2V2
DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2
ubiquitin-conjugating enzyme E2 variant 2
GO Process (7)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Comprehensive ubiquitin E2 profiling of ten ubiquitin E3 ligases.
The ubiquitin pathway regulates diverse functions including protein localization and stability. The complexity of the pathway involving nearly 40 identified E2 conjugating enzymes and over 600 E3 ligases raises the issue of specificity. With the E2s and E3s fitting into a limited number of classes based on bioinformatics, structures, and proven activities, there is not a clear picture as to ... [more]
Cell Biochem. Biophys. Sep. 01, 2013; 67(1);161-7 [Pubmed: 23695783]
Throughput
- Low Throughput
Additional Notes
- E2
Curated By
- BioGRID