BAIT
PPARG
Nr1c3, PPAR-gamma, PPAR-gamma2, PPARgamma, PPARgamma2
peroxisome proliferator activated receptor gamma
GO Process (55)
GO Function (19)
GO Component (5)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- brown fat cell differentiation [IDA]
- cell fate commitment [IGI]
- cell maturation [ISO]
- cellular response to insulin stimulus [ISO]
- cellular response to lithium ion [IDA]
- cellular response to organic cyclic compound [IDA]
- epithelial cell differentiation [IGI]
- fat cell differentiation [IDA, IGI]
- fatty acid oxidation [ISO]
- glucose homeostasis [ISO]
- inflammatory response [TAS]
- intracellular receptor signaling pathway [TAS]
- lipoprotein transport [ISO]
- long-chain fatty acid transport [IMP]
- low-density lipoprotein particle receptor biosynthetic process [ISO]
- monocyte differentiation [ISO]
- negative regulation of acute inflammatory response [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cellular response to insulin stimulus [IMP]
- negative regulation of cholesterol storage [ISO]
- negative regulation of collagen biosynthetic process [ISO]
- negative regulation of cytokine production [IMP]
- negative regulation of interferon-gamma-mediated signaling pathway [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- negative regulation of pancreatic stellate cell proliferation [ISO]
- negative regulation of peptide hormone secretion [IMP]
- negative regulation of receptor biosynthetic process [ISO]
- negative regulation of sequestering of triglyceride [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of telomerase activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- peroxisome proliferator activated receptor signaling pathway [ISO]
- placenta development [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of fat cell differentiation [IDA, IGI, IMP, ISO]
- positive regulation of fatty acid oxidation [ISO]
- positive regulation of oligodendrocyte differentiation [ISO]
- positive regulation of phagocytosis, engulfment [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of blood pressure [ISO]
- regulation of fat cell differentiation [IDA, IGI, ISO]
- regulation of lipid metabolic process [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO, TAS]
- regulation of transcription involved in cell fate commitment [IMP]
- response to lipid [IDA]
- response to low-density lipoprotein particle [ISO]
- response to retinoic acid [IDA, ISO]
- signal transduction [ISO]
- transcription from RNA polymerase II promoter [IDA]
- white fat cell differentiation [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, IPI, ISO]
- RNA polymerase II regulatory region DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- WW domain binding [ISO]
- activating transcription factor binding [ISO]
- arachidonic acid binding [IDA]
- chromatin binding [IDA]
- drug binding [ISO]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO, TAS]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA, ISO]
- protein binding [IPI]
- protein phosphatase binding [ISO]
- retinoid X receptor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- DNA binding [IDA, IPI, ISO]
- RNA polymerase II regulatory region DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- WW domain binding [ISO]
- activating transcription factor binding [ISO]
- arachidonic acid binding [IDA]
- chromatin binding [IDA]
- drug binding [ISO]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO, TAS]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA, ISO]
- protein binding [IPI]
- protein phosphatase binding [ISO]
- retinoid X receptor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
Mus musculus
PREY
NEDD4
AA959633, AL023035, AU019897, E430025J12Rik, Nedd4-1, Nedd4a, mKIAA0093
neural precursor cell expressed, developmentally down-regulated 4
GO Process (16)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- T cell activation [IMP]
- adaptive immune response [IMP]
- blood vessel morphogenesis [IGI, IMP]
- endocardial cushion development [IGI, IMP]
- negative regulation of sodium ion transport [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- neuromuscular junction development [IMP]
- outflow tract morphogenesis [IGI, IMP]
- positive regulation of protein catabolic process [IDA, ISO]
- protein K63-linked ubiquitination [ISO]
- protein monoubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IMP]
- regulation of dendrite morphogenesis [IMP, ISO]
- regulation of synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells.
Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated nuclear receptor which controls lipid and glucose metabolism. It is also the master regulator of adipogenesis. In adipocytes, ligand-dependent PPARγ activation is associated with proteasomal degradation; therefore, regulation of PPARγ degradation may modulate its transcriptional activity. Here, we show that neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4), an E3 ubiquitin ligase, ... [more]
Sci Rep Dec. 05, 2015; 6();38550 [Pubmed: 27917940]
Throughput
- Low Throughput
Curated By
- BioGRID