BAIT
WDTC1
Gm695, adipose, adp, RP23-32C12.5
WD and tetratricopeptide repeats 1
GO Process (9)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- cellular chemical homeostasis [IMP]
- cellular response to insulin stimulus [IMP]
- glucose metabolic process [IMP]
- in utero embryonic development [IMP]
- multicellular organism growth [IMP]
- negative regulation of catalytic activity [IDA]
- negative regulation of fatty acid biosynthetic process [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell size [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
CYP1B1
CP1B, P4501b1
cytochrome P450, family 1, subfamily b, polypeptide 1
GO Process (40)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- DNA modification [ISO]
- angiogenesis [IMP]
- arachidonic acid metabolic process [IDA, ISO]
- benzene-containing compound metabolic process [ISO]
- blood vessel morphogenesis [IMP]
- cell adhesion [IMP]
- cellular aromatic compound metabolic process [IDA, IMP, ISO]
- cellular response to hydrogen peroxide [IMP]
- cellular response to organic cyclic compound [ISO]
- collagen fibril organization [IMP]
- dibenzo-p-dioxin metabolic process [IMP]
- endothelial cell migration [IMP]
- endothelial cell-cell adhesion [IMP]
- estrogen metabolic process [IDA, ISO]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- membrane lipid catabolic process [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of cell adhesion mediated by integrin [IMP]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IMP]
- nitric oxide biosynthetic process [IMP]
- oxidation-reduction process [IDA]
- positive regulation of DNA biosynthetic process [ISO]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of translation [ISO]
- positive regulation vascular endothelial growth factor production [IMP]
- regulation of reactive oxygen species metabolic process [IMP]
- response to toxic substance [IMP]
- retina vasculature development in camera-type eye [IMP]
- retinal blood vessel morphogenesis [IMP]
- retinal metabolic process [IDA, ISO]
- retinol metabolic process [IDA, ISO]
- steroid metabolic process [ISO]
- toxin metabolic process [IMP]
- trabecular meshwork development [IMP]
- xenobiotic metabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.
WDTC1/Adp encodes an evolutionarily conserved suppressor of lipid accumulation. While reduced WDTC1 expression is associated with obesity in mice and humans, its cellular function is unknown. Here, we demonstrate that WDTC1 is a component of a DDB1-CUL4-ROC1 (CRL4) E3 ligase. Using 3T3-L1 cell culture model of adipogenesis, we show that disrupting the interaction between WDTC1 and DDB1 leads to a ... [more]
EMBO Rep. May. 01, 2016; 17(5);638-47 [Pubmed: 27113764]
Throughput
- High Throughput
Curated By
- BioGRID