BAIT
WDTC1
Gm695, adipose, adp, RP23-32C12.5
WD and tetratricopeptide repeats 1
GO Process (9)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- cellular chemical homeostasis [IMP]
- cellular response to insulin stimulus [IMP]
- glucose metabolic process [IMP]
- in utero embryonic development [IMP]
- multicellular organism growth [IMP]
- negative regulation of catalytic activity [IDA]
- negative regulation of fatty acid biosynthetic process [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell size [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
CSE1L
2610100P18Rik, AA407533, Capts, Cas, Xpo2, RP23-19L12.9
chromosome segregation 1-like (S. cerevisiae)
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.
WDTC1/Adp encodes an evolutionarily conserved suppressor of lipid accumulation. While reduced WDTC1 expression is associated with obesity in mice and humans, its cellular function is unknown. Here, we demonstrate that WDTC1 is a component of a DDB1-CUL4-ROC1 (CRL4) E3 ligase. Using 3T3-L1 cell culture model of adipogenesis, we show that disrupting the interaction between WDTC1 and DDB1 leads to a ... [more]
EMBO Rep. May. 01, 2016; 17(5);638-47 [Pubmed: 27113764]
Throughput
- High Throughput
Curated By
- BioGRID