BAIT
RNF4
SLX5, SNURF, RES4-26
ring finger protein 4
GO Process (12)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- androgen receptor signaling pathway [NAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein K11-linked ubiquitination [ISS]
- protein K48-linked ubiquitination [ISS]
- protein K6-linked ubiquitination [ISS]
- protein K63-linked ubiquitination [ISS]
- protein autoubiquitination [ISS]
- regulation of kinetochore assembly [IMP]
- regulation of spindle assembly [IMP]
- response to arsenic-containing substance [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
WFS1
CTRCT41, WFRS, WFS, WFSL
Wolfram syndrome 1 (wolframin)
GO Process (27)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- ER overload response [IC, TAS]
- ER-associated ubiquitin-dependent protein catabolic process [ISS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- calcium ion homeostasis [IDA]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum calcium ion homeostasis [IDA]
- endoplasmic reticulum unfolded protein response [ISS, TAS]
- glucose homeostasis [IMP]
- kidney development [IMP]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [ISS]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of programmed cell death [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISS]
- negative regulation of type B pancreatic cell apoptotic process [IMP]
- neurological system process [IMP]
- polyubiquitinated misfolded protein transport [ISS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of growth [ISS]
- positive regulation of protein metabolic process [IDA]
- positive regulation of protein ubiquitination [ISS]
- positive regulation of proteolysis [ISS]
- protein maturation by protein folding [IC]
- protein stabilization [ISS]
- renal water homeostasis [IMP]
- response to endoplasmic reticulum stress [IDA]
- sensory perception of sound [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.
SUMO-targeted ubiquitin ligases (STUbLs) mediate the ubiquitylation of SUMOylated proteins to modulate their functions. In search of direct targets for the STUbL RNF4, we have developed TULIP (targets for ubiquitin ligases identified by proteomics) to covalently trap targets for ubiquitin E3 ligases. TULIP methodology could be widely employed to delineate E3 substrate wiring. Here we report that the single SUMO ... [more]
Nat Commun Dec. 27, 2016; 8(1);1809 [Pubmed: 29180619]
Throughput
- High Throughput
Curated By
- BioGRID