BAIT
SHARPIN
SIPL1, PSEC0216
SHANK-associated RH domain interactor
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EMD
EDMD, LEMD5, STA, XX-FW88778H2.1
emerin
GO Process (10)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- cellular response to growth factor stimulus [IMP]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- mitotic nuclear envelope reassembly [TAS]
- muscle contraction [TAS]
- muscle organ development [TAS]
- negative regulation of catenin import into nucleus [IMP]
- negative regulation of fibroblast proliferation [IMP]
- positive regulation of protein export from nucleus [IMP]
- regulation of canonical Wnt signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.
Sharpin, a multifunctional adaptor protein, regulates several signalling pathways. For example, Sharpin enhances signal-induced NF-κB signalling as part of the linear ubiquitin assembly complex (LUBAC) and inhibits integrins, the T cell receptor, caspase 1 and PTEN. However, despite recent insights into Sharpin and LUBAC function, a systematic approach to identify the signalling pathways regulated by Sharpin has not been reported. ... [more]
J. Cell. Sci. Sep. 15, 2017; 130(18);3094-3107 [Pubmed: 28775156]
Throughput
- High Throughput
Curated By
- BioGRID