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BAIT

CHD4

CHD-4, Mi-2b, Mi2-BETA

chromodomain helicase DNA binding protein 4

GO Process (3)

GO Function (7)

GO Component (8)

Gene Ontology Biological Process

ATP-dependent chromatin remodeling [IDA]

DNA duplex unwinding [TAS]

regulation of transcription from RNA polymerase II promoter [TAS]

Gene Ontology Molecular Function

ATP-dependent DNA helicase activity [TAS]
DNA binding [TAS]
RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
RNA polymerase II repressing transcription factor binding [IPI]
nucleosomal DNA binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

NuRD complex [IDA]

centrosome [IDA]

cytoplasm [IDA]

nuclear chromatin [IDA]

nucleoplasm [IDA]

protein complex [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

EEF1A1

CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1, RP11-505P4.2

eukaryotic translation elongation factor 1 alpha 1

GO Process (5)

GO Function (5)

GO Component (8)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

cellular response to epidermal growth factor stimulus [IDA]

gene expression [TAS]

translation [TAS]

translational elongation [TAS]

Gene Ontology Molecular Function

GTP binding [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase binding [IPI]
translation elongation factor activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA, ISS, TAS]

eukaryotic translation elongation factor 1 complex [TAS]

extracellular space [IDA]

extracellular vesicular exosome [IDA]

nucleolus [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

Hoffmeister H, Fuchs A, Erdel F, Pinz S, Groebner-Ferreira R, Bruckmann A, Deutzmann R, Schwartz U, Maldonado R, Huber C, Dendorfer AS, Rippe K, Laengst G

CHD3 and CHD4 (Chromodomain Helicase DNA binding protein), two highly similar representatives of the Mi-2 subfamily of SF2 helicases, are coexpressed in many cell lines and tissues and have been reported to act as the motor subunit of the NuRD complex (nucleosome remodeling and deacetylase activities). Besides CHD proteins, NuRD contains several repressors like HDAC1/2, MTA2/3 and MBD2/3, arguing for ... [more]

Nucleic Acids Res. Oct. 13, 2017; 45(18);10534-10554 [Pubmed: 28977666]

Throughput

High Throughput

Curated By

BioGRID