CYLD
Gene Ontology Biological Process
- cytoplasmic translation [IBA]
- necroptotic process [IBA, ISO]
- negative regulation of NF-kappaB import into nucleus [ISO, ISS]
- negative regulation of NF-kappaB transcription factor activity [IBA, ISO, ISS]
- negative regulation of T cell differentiation [ISO]
- negative regulation of canonical Wnt signaling pathway [ISO, ISS]
- positive regulation of extrinsic apoptotic signaling pathway [IBA, ISO]
- protein K63-linked deubiquitination [IBA, ISO, ISS]
- protein deubiquitination [ISO]
- regulation of cilium assembly [ISS]
- regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- regulation of microtubule cytoskeleton organization [ISO]
- regulation of mitotic cell cycle [IBA, ISO]
- ripoptosome assembly involved in necroptotic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NOX4
Gene Ontology Biological Process
- aging [IEP]
- bone resorption [ISO]
- cardiac muscle cell differentiation [ISO]
- cell aging [ISO, ISS]
- cell morphogenesis [ISO, ISS]
- cellular response to cAMP [IEP]
- cellular response to gamma radiation [IEP]
- cellular response to transforming growth factor beta stimulus [IEP]
- homocysteine metabolic process [ISO]
- negative regulation of cell proliferation [ISO, ISS]
- oxidation-reduction process [ISO, ISS]
- positive regulation of DNA biosynthetic process [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of stress fiber assembly [IMP]
- reactive oxygen species metabolic process [ISO, ISS]
- response to hypoxia [IEP]
- superoxide anion generation [ISO, ISS]
- superoxide metabolic process [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling.
Transdifferentiation of adventitial fibroblasts (AFs) into myofibroblasts plays a critical role during the vascular remodeling that occurs during atherosclerosis, restenosis, and aortic aneurysm. The ubiquitination/deubiquitination regulatory system is essential for the quality control of proteins. The involvement of ubiquitination/deubiquitination during AF transdifferentiation remains largely unknown. In this study, we determined the role of cylindromatosis (CYLD), a deubiquitinase, in the process ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NOX4 CYLD | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID