BAIT
ARIH1
ARI, HARI, HHARI, UBCH7BP, HUSSY-27
ariadne RBR E3 ubiquitin protein ligase 1
GO Process (3)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SEC13
D3S1231E, SEC13L1, SEC13R, npp-20
SEC13 homolog (S. cerevisiae)
GO Process (10)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
- COPII vesicle coating [TAS]
- ER to Golgi vesicle-mediated transport [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- intracellular protein transport [NAS]
- membrane organization [TAS]
- mitotic cell cycle [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.
Hundreds of human cullin-RING E3 ligases (CRLs) modify thousands of proteins with ubiquitin (UB) to achieve vast regulation. Current dogma posits that CRLs first catalyze UB transfer from an E2 to their client substrates and subsequent polyubiquitylation from various linkage-specific E2s. We report an alternative E3-E3 tagging cascade: many cellular NEDD8-modified CRLs associate with a mechanistically distinct thioester-forming RBR-type E3, ARIH1, ... [more]
Cell Aug. 25, 2016; 166(5);1198-1214.e24 [Pubmed: 27565346]
Throughput
- High Throughput
Additional Notes
- MLN4924
Curated By
- BioGRID