BAIT
BTG1
B-cell translocation gene 1, anti-proliferative
GO Process (8)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- cell migration [NAS]
- negative regulation of cell growth [NAS]
- negative regulation of cell proliferation [IDA]
- positive regulation of angiogenesis [IMP]
- positive regulation of endothelial cell differentiation [IMP]
- positive regulation of fibroblast apoptotic process [IMP]
- positive regulation of myoblast differentiation [IDA, NAS]
- regulation of transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
CDKN2D
INK4D, p19, p19-INK4D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
GO Process (15)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- DNA synthesis involved in DNA repair [IMP]
- G1/S transition of mitotic cell cycle [IDA]
- autophagic cell death [IMP]
- cell cycle arrest [IDA]
- mitotic cell cycle [TAS]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of phosphorylation [IDA]
- negative regulation of protein serine/threonine kinase activity [IDA]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- response to UV [IMP]
- response to retinoic acid [IMP]
- response to vitamin D [IMP]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
High-throughput binary protein interaction mapping is continuing to extend our understanding of cellular function and disease mechanisms. However, we remain one or two orders of magnitude away from a complete interaction map for humans and other major model organisms. Completion will require screening at substantially larger scales with many complementary assays, requiring further efficiency gains in proteome-scale interaction mapping. Here, ... [more]
Mol. Syst. Biol. Apr. 22, 2016; 12(4);863 [Pubmed: 27107012]
Throughput
- High Throughput
Curated By
- BioGRID