LDLRAP1
Gene Ontology Biological Process
- amyloid precursor protein metabolic process [IMP]
- cholesterol homeostasis [IMP]
- cholesterol metabolic process [NAS]
- positive regulation of cholesterol metabolic process [IC]
- positive regulation of receptor-mediated endocytosis [IMP]
- positive regulation of signal transduction [IDA]
- receptor internalization [IMP]
- receptor-mediated endocytosis [IDA]
- receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [IMP]
- regulation of establishment of protein localization to plasma membrane [IMP]
- regulation of protein binding [IMP]
- transport [NAS]
Gene Ontology Molecular Function- AP-2 adaptor complex binding [IDA]
- beta-amyloid binding [IPI]
- clathrin adaptor activity [IDA]
- clathrin binding [IDA]
- low-density lipoprotein particle receptor binding [IPI]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphotyrosine binding [IDA]
- protein binding [IPI]
- receptor signaling complex scaffold activity [IMP]
- signaling adaptor activity [IDA]
- AP-2 adaptor complex binding [IDA]
- beta-amyloid binding [IPI]
- clathrin adaptor activity [IDA]
- clathrin binding [IDA]
- low-density lipoprotein particle receptor binding [IPI]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphotyrosine binding [IDA]
- protein binding [IPI]
- receptor signaling complex scaffold activity [IMP]
- signaling adaptor activity [IDA]
Gene Ontology Cellular Component
AP2B1
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- clathrin-mediated endocytosis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of defense response to virus by virus [TAS]
- synaptic transmission [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
High-throughput binary protein interaction mapping is continuing to extend our understanding of cellular function and disease mechanisms. However, we remain one or two orders of magnitude away from a complete interaction map for humans and other major model organisms. Completion will require screening at substantially larger scales with many complementary assays, requiring further efficiency gains in proteome-scale interaction mapping. Here, ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LDLRAP1 AP2B1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| AP2B1 LDLRAP1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2694078 | |
| AP2B1 LDLRAP1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID