BAIT
AXIN1
AXIN, PPP1R49, LA16c-314G4.3
axin 1
GO Process (33)
GO Function (13)
GO Component (12)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IBA]
- Wnt-activated signaling pathway involved in forebrain neuron fate commitment [IBA]
- activation of JUN kinase activity [IBA]
- activation of protein kinase activity [IDA]
- axial mesoderm formation [IBA]
- canonical Wnt signaling pathway [IC]
- canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [IBA]
- cell death [IBA]
- cellular protein complex assembly [IDA]
- cellular response to organic cyclic compound [IBA]
- cytoplasmic microtubule organization [IBA]
- determination of left/right symmetry [IBA]
- dorsal/ventral axis specification [IBA]
- embryonic eye morphogenesis [IBA]
- embryonic skeletal joint morphogenesis [IBA]
- forebrain anterior/posterior pattern specification [IBA]
- muscle cell development [IBA]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of canonical Wnt signaling pathway [IBA]
- negative regulation of fat cell differentiation [IBA]
- olfactory placode formation [IBA]
- optic placode formation [IBA]
- positive regulation of GTPase activity [IBA]
- positive regulation of JNK cascade [ISS]
- positive regulation of peptidyl-serine phosphorylation [NAS]
- positive regulation of peptidyl-threonine phosphorylation [NAS]
- positive regulation of protein catabolic process [IC, IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of protein ubiquitination [NAS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of ubiquitin-protein transferase activity [IMP]
- regulation of catenin import into nucleus [IBA]
Gene Ontology Molecular Function- GTPase activator activity [IBA]
- I-SMAD binding [IPI]
- SMAD binding [IPI]
- armadillo repeat domain binding [IBA, ISS]
- beta-catenin binding [IDA]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein binding [IPI]
- protein complex scaffold [IDA, IMP]
- protein homodimerization activity [ISS]
- protein kinase binding [IBA, ISS]
- signal transducer activity [IDA]
- ubiquitin protein ligase binding [IPI]
- GTPase activator activity [IBA]
- I-SMAD binding [IPI]
- SMAD binding [IPI]
- armadillo repeat domain binding [IBA, ISS]
- beta-catenin binding [IDA]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein binding [IPI]
- protein complex scaffold [IDA, IMP]
- protein homodimerization activity [ISS]
- protein kinase binding [IBA, ISS]
- signal transducer activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- beta-catenin destruction complex [IDA]
- cell cortex [IBA]
- cell periphery [IDA]
- cytoplasm [IDA]
- cytoplasmic membrane-bounded vesicle [IBA]
- cytoplasmic microtubule [IBA]
- cytoplasmic vesicle [ISS]
- cytosol [TAS]
- lateral plasma membrane [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- postsynaptic density [IBA]
Homo sapiens
PREY
JUP
ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB
junction plakoglobin
GO Process (20)
GO Function (9)
GO Component (17)
Gene Ontology Biological Process
- adherens junction organization [TAS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cell junction assembly [TAS]
- cell migration [IMP]
- cell-cell junction organization [TAS]
- cellular response to indole-3-methanol [IDA]
- cytoskeletal anchoring at plasma membrane [NAS]
- desmosome assembly [IDA, IMP]
- detection of mechanical stimulus [IDA]
- endothelial cell-cell adhesion [ISS]
- establishment of protein localization to plasma membrane [IMP]
- positive regulation of canonical Wnt signaling pathway [IC]
- positive regulation of protein import into nucleus [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- single organismal cell-cell adhesion [IDA, IMP]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- catenin complex [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA]
- cytoplasm [IMP]
- cytoplasmic side of plasma membrane [ISS]
- cytoskeleton [ISS]
- cytosol [ISS]
- desmosome [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- gamma-catenin-TCF7L2 complex [IDA]
- hemidesmosome [ISS]
- intercalated disc [IDA]
- nucleus [IMP]
- plasma membrane [IDA, TAS]
- protein-DNA complex [IDA]
- zonula adherens [ISS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
While alternative splicing is known to diversify the functional characteristics of some genes, the extent to which protein isoforms globally contribute to functional complexity on a proteomic scale remains unknown. To address this systematically, we cloned full-length open reading frames of alternatively spliced transcripts for a large number of human genes and used protein-protein interaction profiling to functionally compare hundreds ... [more]
Cell Feb. 11, 2016; 164(4);805-17 [Pubmed: 26871637]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AXIN1 JUP | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1445161 |
Curated By
- BioGRID