BAIT
PROM1
AC133, CD133, CORD12, MCDR2, PROML1, RP41, STGD4, MSTP061
prominin 1
GO Process (7)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- camera-type eye photoreceptor cell differentiation [IMP, ISS]
- glomerular parietal epithelial cell differentiation [IMP]
- glomerular visceral epithelial cell differentiation [IMP]
- photoreceptor cell maintenance [IMP]
- positive regulation of nephron tubule epithelial cell differentiation [IMP]
- retina layer formation [ISS]
- retina morphogenesis in camera-type eye [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LAMP1
CD107a, LAMPA, LGP120
lysosomal-associated membrane protein 1
GO Process (7)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- Golgi to lysosome transport [IMP]
- establishment of protein localization to organelle [IMP]
- granzyme-mediated apoptotic signaling pathway [IMP]
- positive regulation of natural killer cell degranulation [IMP]
- positive regulation of natural killer cell mediated cytotoxicity [IMP]
- protein stabilization [ISS]
- regulation of organelle transport along microtubule [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Monoubiquitination of Cancer Stem Cell Marker CD133 at Lysine 848 Regulates Its Secretion and Promotes Cell Migration.
CD133, a widely known marker of cancer stem cells, was recently found in extracellular vesicles. However, the mechanisms underlying CD133 translocation to the extracellular space remain largely unknown. Here we report that CD133 is monoubiquitinated. Ubiquitination occurs primarily on complex glycosylated CD133. The lysine 848 residue at the intracellular carboxyl terminus is one of the sites for CD133 ubiquitination. The ... [more]
Mol. Cell. Biol. Aug. 01, 2018; 38(15); [Pubmed: 29760280]
Throughput
- Low Throughput
Curated By
- BioGRID