Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway.

Depping R, Steinhoff A, Schindler SG, Friedrich B, Fagerlund R, Metzen E, Hartmann E, Koehler M

Hypoxia-inducible factors are the key elements in the essential process of oxygen homeostasis of vertebrate cells. Stabilisation and subsequent nuclear localisation of HIF-alpha subunits results in the activation of target genes such as vegf, epo and glut1. The passage of transcription factors e.g. HIF-1alpha into the nucleus through the nuclear pore complex is regulated by nuclear transport receptors. Therefore nucleocytoplasmic ... [more]

Biochim. Biophys. Acta Mar. 01, 2008; 1783(3);394-404 [Pubmed: 18187047]

Throughput

  • Low Throughput

Curated By

  • BioGRID